Figure 5.

Control points impinging on ENaC cell surface expression and activity. Schematic representation of the steps involved in regulating α ENaC cell surface expression and activity. These steps include α ENaC subunit synthesis, assembly with the β and γ subunits, trafficking, insertion into the plasma membrane and activity. α ENaC-b may hinder any of these steps causing a suppressed channel cell surface expression and/or activity in Dahl R versus S rats that is augmented on high salt diet.