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Open Access Review

Interleukin 8 (IL-8) - a universal biomarker?

Aamir Shahzad1*, Martin Knapp2, Irene Lang3 and Gottfried Köhler1

Author Affiliations

1 Max F. Perutz Laboratories, Department of Structural Biology and Biomolecular Chemistry, University of Vienna, Vienna, Austria

2 OnkoTec GmbH. Waidhofen/Thaya, Vienna, Austria

3 Division of Cardiology, Department of Internal Medicine II, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

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International Archives of Medicine 2010, 3:11  doi:10.1186/1755-7682-3-11

Published: 15 June 2010

Abstract

Many clinical conditions including various types of cancers are complex and generally require invasive, laborious, expensive and time-consuming investigations for their diagnosis, treatment and follow-up. There is therefore a general need for exploring non-invasive markers in clinical medicine. Interleukin 8 (IL-8) is currently being applied in various subspecialties of medicine either for the purpose of rapid diagnosis or as a predictor of prognosis. Nevertheless, there is need for large-scale studies to substantiate accuracy and outcome. This article will summarize current evidence suggesting that Interleukin 8 (IL-8) may serve as a useful biomarker.