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Open Access Case report

Left ventricular noncompaction and myocardial fibrosis: a case report

Jagadeesh K Kalavakunta1, Hemasri Tokala1, Aparna Gosavi2 and Vishal Gupta1*

Author Affiliations

1 Department of Internal Medicine: Division of Cardiology, Michigan State University/Kalamazoo Center for Medical Studies/Borgess Medical Center, Kalamazoo, MI, USA

2 Department of Internal Medicine: Division of Cardiology, University of Missouri-Columbia, MO, USA

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International Archives of Medicine 2010, 3:20  doi:10.1186/1755-7682-3-20

Published: 15 September 2010



Left ventricular noncompaction (LVNC) is a rare congenital abnormality. It is currently classified as a genetic cardiomyopathy and results from early arrest of endomyocardial morphogenesis. The pathophysiology of left ventricular dysfunction, which becomes apparent beyond the 4th decade of life, is unclear.

Case report

We report a case of 60-year-old woman who presented with shortness of breath and showed noncompacted endocardium on echocardiography. Cardiac catheterization and viral studies were unremarkable. Histology revealed endomyocardial fibrosis without disarray. She was subsequently diagnosed with LVNC and treated with medications.


Cardiologists and other physicians should be aware of LVNC due to its high likelihood of misdiagnosis and associated high complication rates. Early diagnosis, intervention and screening among family members can decrease the morbidity and mortality associated with LVNC.