Email updates

Keep up to date with the latest news and content from International Archives of Medicine and BioMed Central.

Open Access Highly Accessed Review

Dopaminergic reward system: a short integrative review

Oscar Arias-Carrión12*, Maria Stamelou2, Eric Murillo-Rodríguez3, Manuel Menéndez-González4 and Ernst Pöppel1

Author Affiliations

1 Human Science Center (FESTO-Program for Applied Knowing). Ludwig-Maximilians-Universität. Munich, Germany

2 Department of Neurology, Philipps-Universität. Marburg, Germany

3 Laboratorio de Neurociencias Moleculares e Integrativas. Escuela de Medicina, División Ciencias de la Salud. Universidad Anáhuac Mayab. Mérida, Yucatán. México

4 Unit of Neurology, Hospital Alvarez-Buylla, Mieres, Spain

For all author emails, please log on.

International Archives of Medicine 2010, 3:24  doi:10.1186/1755-7682-3-24

Published: 6 October 2010


Memory is an essential element to adaptive behavior since it allows consolidation of past experience guiding the subject to consider them in future experiences. Among the endogenous molecules that participate in the consolidation of memory, including the drug-seeking reward, considered as a form of learning, is dopamine. This neurotransmitter modulates the activity of specific brain nucleus such as nuclei accumbens, putamen, ventral tegmental area (VTA), among others and synchronizes the activity of these nuclei to establish the neurobiological mechanism to set the hedonic element of learning. We review the experimental evidence that highlights the activity of different brain nuclei modulating the mechanisms whereby dopamine biases memory towards events that are of motivational significance.