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Open Access Case report

A young adult presenting with granulomatous hepatitis and nephrotic syndrome: A case report

Kumarangie Vithanage* and Kanpathipillai Thirumavalavan

Author Affiliations

Department of Medicine (Ward 13), Colombo North Teaching Hospital, Colombo, Sri Lanka

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International Archives of Medicine 2012, 5:29  doi:10.1186/1755-7682-5-29

Published: 25 October 2012


Amyloidosis is a rare disease characterised by the deposition of insoluble extracellular fibrillar proteins in various tissues of the body. The pattern of manifestation is organ dependent and also on whether the disease is localised or systemic, primary or secondary. Primary systemic amyloidosis is a disease of adulthood. In reported cases, the mean patient age of onset is 65 years. We report a case of a young adult who presented with jaundice and leg oedema which ultimately found to have granulomatous hepatitis and nephrotic syndrome secondary to systemic amyloidosis. The purpose of this case report is to reiterate the importance of a high index of suspicion in considering amyloidosis in such presentations regardless of the presenting age.